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Systematic characterization of DE droplets – By studying correlations between flow rates, droplet size, and device geometries, we are systematically optimizing DE droplet generation and testing fundamental droplet fluid physics and surfactant compatibility in complex interfaces.
Multi-parameter single-cell analysis – Using sortable double emulsions, we are developing assays to simultaneously screen for rare cell populations and characterize downstream single cell gene expression (RNA-Seq) or epigenomic signatures (ATAC-Seq). The goal of these efforts is to enable new droplet-based techniques that allow tandem ‘omics measurements on the same single cell.
Characterization of individual plant cells at scale – The flexibility of double emulsion droplets permits us to bring single-cell analysis tools to new organisms and new assays. We are developing new ways to measure the transcriptomic profiles and phenotypes of individual rare plant cells of interest.