Organoid models of cancer have revolutionized our ability to recapitulate and observe in vivo cancer processes in a controlled in vitro environment. We are collaborating with Christina Curtis and Calvin Kuo to develop a microwell platform for performing high-throughput phenotyping of organoid heterogeneity across tumor development. This platform allows us to perform time-lapse imaging of thousands of organoids isolated in microwells, followed by computational reconstruction of growth trajectories for each organoid.
